Which of the following parameters are useful clinical predictors of a diagnosis of IPF?



HRCT interstitial score

Pulmonary function

6-minute Walk Distance

Desaturation during 6-minute Walk Test

Author’s solution
Age and extent of interstitial abnormalities on HRCT seem to be clinical predictors for an underlying UIP pathology pattern (OR: 1.11 and 17.20 respectively).
This observation is of clinical value as it can support a “working diagnosis” of IPF in a patient with a compatible history and HRCT findings and obviate the need for lung biopsy.

Raghu G et al. Am J Respir Crit Care Med 2006;174:810–816.
Fell CD et al. Am J Respir Crit Care Med 2010;181:832-837.